Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β
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چکیده
منابع مشابه
Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β
In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease progression. The molecular basis of GC insensitivity, however, is unknown. Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-beta, which does not bind GCs but antagonizes the transactivating activity o...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1997
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.186.9.1567